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Disease Name: Hemolytic-Uremic Syndrome (HUS)

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Please review the Idaho Reportable Disease Rules (IDAPA 16.02.10) for the most up-to-date information.

Overview / Case Definition

Clinical description

Hemolytic uremic syndrome (HUS) is characterized by the acute onset of microangiopathic hemolytic anemia, renal injury, and low platelet count. Thrombotic thrombocytopenic purpura (TTP) also is characterized by these features but can include central nervous system (CNS) involvement and fever and may have a more gradual onset. Most cases of HUS (but few cases of TTP) occur after an acute gastrointestinal illness (usually diarrheal).

Laboratory criteria for diagnosis

The following are both present at some time during the illness:

Note: A low platelet count can usually, but not always, be detected early in the illness, but it may then become normal or even high. If a platelet count obtained within 7 days after onset of the acute gastrointestinal illness is not less than 150,000/mm3, other diagnoses should be considered.




Within 1 working day

Reportable by Healthcare and Labs:

Reportable by Food Service Facility:

Suspect Reportable:

Reporting Timeframe: Within 1 working day

Diagnosis / Testing

Analysis may include strain determination, toxin analysis, and PFGE comparisons with other isolates from similar cases occurring in a temporal or spatially similar manner. Sometimes diagnosis is made on toxin analysis alone.


Additional Information

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